Analytical Data
-
Gene name
FGFR-2 alpha (IIIc)
-
简介
The FGFR-2 α IIIc protein is a tyrosine protein kinase receptor for fibroblast growth factor and is critical for embryonic development, regulating proliferation, differentiation, and apoptosis. Its importance is evident in embryonic patterning, trophoblast function, limb bud development, lung morphogenesis, osteogenesis, and skin development. FGFR-2 alpha (IIIc) Protein, Human (HEK293, His-Fc) is the recombinant human-derived FGFR-2 alpha IIIc protein, expressed by HEK293 , with C-hFc, C-His labeled tag.
- Application
-
Alternative Names
Fibroblast growth factor receptor 2; FGFR-2; KSAM; KGFR; CD332; BEK
-
Species
Human
-
Source
HEK293
-
Tag
C-hFc;C-His
-
Purity
Greater than 90% as determined by SDS-PAGE.
-
Uniprot
P21802-1
-
Expression Region
R22-E377
-
Protein Length
Extracellular Domain
-
Molecular Weight
110-120 kDa
-
Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
-
Form
Freeze-dried powder
-
Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
-
Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
FGFR-2 alpha (IIIc) is an important member of the fibroblast growth factor receptor (FGFR) family, which plays a crucial role in various biological processes, including cell proliferation, differentiation, and survival. Alterations in FGFR signaling have been implicated in a range of diseases, particularly cancer, making it an attractive target for therapeutic intervention. Research has shown that specific isoforms, such as FGFR-2 alpha (IIIc), are involved in both normal physiological processes and pathological conditions. The expression of this receptor isoform is often upregulated in tumors, contributing to malignant behavior and metastasis. Consequently, FGFR-2 alpha (IIIc) has emerged as a focal point in cancer research and targeted therapy development. Recombinant proteins of FGFR-2 alpha (IIIc) are being studied to understand its structural and functional properties, which can provide insights into receptor-ligand interactions and intracellular signaling pathways. This research aims to elucidate the mechanistic roles of FGFR-2 alpha (IIIc) in oncology, paving the way for the development of FGFR-targeted therapies, including monoclonal antibodies and small molecule inhibitors. Furthermore, by generating and characterizing recombinant FGFR-2 alpha (IIIc), researchers can explore potential biomarkers for cancer diagnosis and prognosis, highlighting the significance of this receptor in clinical settings. Overall, the study of FGFR-2 alpha (IIIc) is pivotal for advancing our understanding of its biological significance and therapeutic potential in various diseases, especially in the context of cancer treatment.
