Analytical Data
-
Gene name
HDAC1
- Application
-
Alternative Names
HDAC1; GON10; HD1; RPD3; RPD3L1
-
Species
Human
-
Source
E. coli
-
Tag
N-His
-
Purity
Greater than 90% as determined by SDS-PAGE.
-
Uniprot
Q13547
-
Expression Region
Met1~Ala482
-
Molecular Weight
22&70kDa
-
Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
-
Form
Freeze-dried powder
-
Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
-
Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
Histone deacetylase 1 (HDAC1) is a crucial enzyme involved in the regulation of gene expression through the removal of acetyl groups from histone proteins, leading to chromatin condensation and transcriptional repression. Dysregulation of HDAC1 has been implicated in various diseases, particularly in cancer, where altered histone acetylation patterns contribute to oncogenesis. The study of recombinant HDAC1 proteins provides valuable insights into the enzyme's functional mechanisms, substrate specificity, and interactions with other cellular proteins. Research on HDAC1 is not only essential for understanding its role in epigenetic regulation but also for the development of novel therapeutic strategies, such as HDAC inhibitors, which have shown promise in reversing aberrant gene expression in cancer and other diseases. By generating and analyzing recombinant HDAC1, scientists can investigate its enzymatic activity, explore its role in cellular processes, and potentially identify new pathways for intervention in HDAC1-related pathologies.
