Analytical Data
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Gene name
FGFR-1
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简介
FGFR-1 protein is a tyrosine-protein kinase that acts as a cell surface receptor for fibroblast growth factor and plays a critical role in the complex regulation of embryonic development, cell proliferation, differentiation, and migration. FGFR-1 mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1, MAP kinase signaling pathways, and AKT1 signaling pathways. FGFR-1 Protein, Rhesus Macaque (HEK293, Fc) is the recombinant Rhesus Macaque-derived FGFR-1 protein, expressed by HEK293 , with C-hFc labeled tag.
- Application
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Alternative Names
Fibroblast growth factor receptor 1; FGFR-1; BFGFR; FLT-2; CD331; HBGFR
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Species
Rhesus Macaque
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Source
HEK293
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Tag
C-hFc
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
H9FRD4
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Expression Region
R22-Y283
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Protein Length
Partial
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Fibroblast growth factor receptor 1 (FGFR-1) is a critical receptor in the signaling pathways that regulate various biological processes, including cell proliferation, differentiation, and survival. Its dysregulation has been implicated in a variety of pathological conditions, notably cancer and skeletal disorders. Researchers have observed that mutations, amplifications, or overexpression of FGFR-1 can lead to tumorigenesis, making it a potential biomarker and therapeutic target in oncology. In this context, the generation of recombinant FGFR-1 protein has garnered significant attention, facilitating detailed studies of its structure and function. Such recombinant proteins allow for the exploration of FGFR-1's interactions with its ligands and downstream signaling molecules, thus providing insights into its role in normal physiology and disease states. Furthermore, understanding the structural aspects of FGFR-1 through recombinant technology is crucial for the development of FGFR-targeted therapies. This includes the design of small-molecule inhibitors or monoclonal antibodies aimed at blocking this receptor’s activity in malignancies characterized by FGFR-1 aberrations. Overall, research on FGFR-1 recombinant proteins is vital for elucidating the biological mechanisms underlying its function, paving the way for innovative therapeutic strategies to combat related diseases.
