Analytical Data
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Gene name
PSPN
- Application
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Alternative Names
PSP
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Species
Human
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Source
E. coli
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Tag
N- His & GST
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
O60542
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Expression Region
Val29~Gly156
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Molecular Weight
44kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
PSPN (Proteolipid Protein 1), a critical component of myelin in the central nervous system, has garnered significant interest in research due to its key role in the formation and maintenance of myelin sheaths. Myelin sheaths are essential for the proper functioning of neuronal communication, as they facilitate the rapid transmission of electrical impulses along axons. Disruptions in myelin integrity are implicated in various neurological disorders, including multiple sclerosis and leukodystrophies. Recent studies have focused on the biochemical and structural characterization of PSPN to better understand its functions and interactions within myelin. Advancements in techniques such as cryo-electron microscopy and X-ray crystallography have allowed researchers to elucidate the molecular organization of PSPN and its impact on myelin stability. Additionally, studies investigating the mutations in the PSPN gene have provided insights into how alterations in its expression and function may lead to demyelination and neurological deficits. Understanding the role of PSPN not only aids in comprehending myelination processes but also paves the way for potential therapeutic strategies aimed at repairing myelin damage and treating related diseases. As the field progresses, the ongoing exploration of PSPN could unveil novel pathways for intervention and enhance our understanding of myelin-associated disorders.
