Analytical Data
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Gene name
FGFR-1 beta (IIIb)
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简介
FGFR-1 beta is a member of the FGFR family that interacts with fibroblast growth factors and regulates mitosis and differentiation. It specifically binds acidic and basic fibroblast growth factors and is involved in limb induction. FGFR-1 beta (IIIb) Protein, Human (HEK293, Fc) is a recombinant protein dimer complex containing human-derived FGFR-1 beta, expressed by HEK293 , with C-hFc labeled tag. FGFR-1 beta (IIIb) Protein, Human (HEK293, Fc), has molecular weight of 76-106 kDa.
- Application
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Alternative Names
Fibroblast growth factor receptor 1; FGFR-1; FGF R1b; FGFR1 beta
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Species
Human
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Source
HEK293
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Tag
C-hFc
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P11362-14
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Expression Region
P11362-14/NP_075594.1 (R22-K221&A270-E285)&AAB19502 (H1-P47)
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Molecular Weight
76-106 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
FGFR-1 beta (IIIb) is a member of the fibroblast growth factor receptor (FGFR) family, which plays a critical role in various physiological processes, including cell proliferation, differentiation, and angiogenesis. Alterations in FGFR signaling have been implicated in a range of diseases, particularly in various types of cancers and skeletal disorders. The beta (IIIb) isoform of FGFR-1, generated through alternative splicing, is predominantly expressed in epithelial tissues and is known to have distinct functional properties compared to other isoforms. Research focusing on FGFR-1 beta (IIIb) has gained prominence due to its involvement in tumorigenesis and its potential as a therapeutic target. By studying recombinant FGFR-1 beta (IIIb) protein, researchers aim to elucidate its structural features, binding affinities, and interaction with specific ligands, all of which are crucial for understanding its role in cell signaling pathways. Additionally, the development of targeted therapies that inhibit FGFR signaling holds promise for improving treatment outcomes in FGFR-related malignancies. Overall, the investigation of FGFR-1 beta (IIIb) recombinant protein is essential for advancing our understanding of its biological functions and therapeutic applications in oncology and regenerative medicine.
