Analytical Data
-
Gene name
MHCB
- Application
-
Alternative Names
MHC-B; HLA-B; HLAB; AS; SPDA1; Leukocyte Antigen B; Ankylosing Spondylitis; HLA class I histocompatibility antigen, B-7 alpha chain
-
Species
Human
-
Source
E. coli
-
Tag
N-His
-
Purity
Greater than 90% as determined by SDS-PAGE.
-
Uniprot
P01889
-
Expression Region
Ser26~Val309
-
Molecular Weight
37kDa
-
Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
-
Form
Freeze-dried powder
-
Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
-
Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
The study of the MHCB (Major Histocompatibility Complex class II-like molecule) recombinant proteins has garnered significant interest in immunology and vaccine development due to their critical role in the immune response. MHCB molecules are pivotal for presenting peptide antigens to CD4+ T cells, thereby influencing the adaptive immune response. Understanding the structure and function of MHCB proteins can enhance our grasp of immune system mechanisms and facilitate the design of more effective immunotherapies and vaccines. Researchers aim to unravel the complexities of MHCB interactions with T cell receptors and their involvement in immune evasion by pathogens, which is particularly relevant for conditions like cancer and chronic infections. The production of recombinant MHCB proteins allows for in-depth studies, including their role in antigen processing, presentation, and the subsequent activation of T cells. This research is essential for the advancement of personalized medicine strategies, where specific MHCB alleles can be targeted for tailored vaccine design against various diseases. Furthermore, elucidating the functional dynamics of these proteins can lead to breakthroughs in transplant immunology, helping to mitigate rejection and improve graft survival rates. As the understanding of MHCB continues to expand, the potential for innovative therapeutic applications remains vast, making it a crucial area of research in modern biomedical science.
