Analytical Data
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基因名
IRF4
- Application
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别名
LSIRF; MUM1; NF-EM5; Lymphocyte-specific interferon regulatory factor; Multiple myeloma oncogene 1
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种属
Mouse
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表达系统
E. coli
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标签
N-His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q64287
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表达区间
Asp175~His433
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分子量
33kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
IRF4 (Interferon Regulatory Factor 4) is a member of the IRF family of transcription factors, playing a crucial role in the regulation of immune responses, particularly in lymphocyte differentiation and function. Its significance has been highlighted in various contexts, such as its involvement in the development and activation of B cells, T cells, and dendritic cells. Dysregulation of IRF4 has been implicated in several pathological conditions, including autoimmune diseases and cancers, particularly in multiple myeloma and certain lymphomas. Recent studies have aimed to understand the molecular mechanisms governing IRF4's activity and its interactions with other signaling pathways. The recombinant expression of IRF4 protein allows for in-depth investigations into its functional roles and facilitates the exploration of its potential as a therapeutic target. Understanding the structural and functional properties of IRF4 is critical for elucidating its contributions to immune regulation and disease, providing insights that could lead to novel approaches in immunotherapy and personalized medicine. This background underscores the importance of IRF4 research in the broader context of immunology and oncology, highlighting its potential as a focal point in developing innovative treatment strategies.
