Analytical Data
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Gene name
SLC25A15
- Application
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Alternative Names
Solute carrier family 25 member 15
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Species
Human
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Source
E. coli
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Tag
N- GST
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9Y619
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Expression Region
1-301aa
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Molecular Weight
59.7 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
SLC25A15, also known as the mitochondrial ornithine transporter, is a crucial protein encoded by the SLC25A15 gene, which plays a significant role in the urea cycle and amino acid metabolism. The importance of SLC25A15 lies in its function of transporting ornithine across the mitochondrial membrane, facilitating the conversion of ammonia into urea in the liver and supporting various metabolic pathways. Research on SLC25A15 has gained momentum due to its association with several metabolic disorders, particularly hyperornithinemia-hyperammonaemia-homocitrullinuria syndrome (HHH syndrome), a genetic condition characterized by elevated levels of ornithine and ammonia in the bloodstream, leading to neurological complications. Understanding the structure and function of SLC25A15, including the dynamics of its transport mechanism, is critical for deciphering its biological role and the pathophysiology of related diseases. The recombinant expression of SLC25A15 in heterologous systems allows for detailed biochemical studies, providing insights into its substrate specificity, transport kinetics, and potential regulatory mechanisms. Additionally, characterizing the recombinant protein can lead to the identification of novel therapeutic targets and the development of strategies to mitigate the effects of associated metabolic disorders. Overall, the investigation of SLC25A15 recombinant protein is pivotal in bridging the gap between molecular biology and clinical applications, aiming at improving the understanding and treatment options for patients affected by conditions linked to this important transporter.
