Analytical Data
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基因名
BAFF
- Application
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别名
CD257; TNFSF13B; BLYS; TALL1; THANK; TNFSF20; ZTNF4; B lymphocyte stimulator; Tumor Necrosis Factor Ligand Superfamily Member 13B; Dendritic cell-derived TNF-like
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种属
Human
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表达系统
E. coli
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标签
N-His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9Y275
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表达区间
Gln68~Leu285
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分子量
45kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
BAFF (B-cell activating factor) is a critical cytokine belonging to the TNF superfamily that plays a pivotal role in B cell development, survival, and activation. It is primarily produced by myeloid cells and is essential for maintaining B cell homeostasis and regulating immune responses. Aberrant expression of BAFF has been linked to various autoimmune diseases, such as systemic lupus erythematosus (SLE) and rheumatoid arthritis, highlighting its importance in pathophysiology. Research on recombinant BAFF protein has gained momentum as it provides a valuable tool for studying B cell biology and the underlying mechanisms of immune disorders. The production of recombinant BAFF enables researchers to investigate its structural properties and functional roles in different biological contexts. Moreover, understanding how BAFF interacts with its receptors, BAFF-R, TACI, and BCMA, is crucial for developing targeted therapies that modulate immune responses. Pioneering studies have shown that blocking BAFF with antagonistic agents can reduce autoimmune activity, suggesting its potential as a therapeutic target. Overall, the study of recombinant BAFF protein is instrumental in unraveling the complexities of B cell regulation and identifying novel strategies for treating immune-related diseases.
