Analytical Data
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Gene name
TIMM10B
- Application
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Alternative Names
Fracture callus protein 1FxC1Mitochondrial import inner membrane translocase subunit Tim9 BTIMM10B ;Tim10b
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Species
Human
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Source
E. coli
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Tag
N- His-SUMO
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9Y5J6
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Expression Region
1-103aa
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Molecular Weight
27.6 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
TIMM10B, a member of the mitochondrial import machinery, plays a critical role in the biogenesis of mitochondrial proteins, which are essential for cellular energy metabolism and overall cellular health. As a chaperone protein, TIMM10B facilitates the correct folding and assembly of precursor proteins within the mitochondria, ensuring that these proteins can function effectively in the electron transport chain and other mitochondrial processes. Recent research has highlighted its significance in various physiological and pathological conditions, including metabolic disorders and neurodegenerative diseases. Understanding the structure and function of TIMM10B can provide insights into mitochondrial dysfunction, which is implicated in a wide array of diseases. The study of TIMM10B also opens avenues for potential therapeutic interventions aimed at restoring mitochondrial function, thus emphasizing its relevance in both basic and applied biomedical research. The ongoing exploration of its interactions with other mitochondrial proteins and its regulatory mechanisms will further elucidate its role in mitochondrial dynamics and cellular homeostasis. Through advancements in recombinant DNA technology, the production and characterization of TIMM10B recombinant proteins have become feasible, enabling detailed functional analyses and the potential development of novel therapeutic strategies targeting mitochondrial diseases.
