Analytical Data
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Gene name
UBE2D4
- Application
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Alternative Names
E2 ubiquitin-conjugating enzyme D4 HBUCE1 Ubiquitin carrier protein D4 Ubiquitin-protein ligase D4
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Species
Human
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Source
E. coli
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Tag
N- GST
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9Y2X8
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Expression Region
1-147aa
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Molecular Weight
43.6 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
UBE2D4, a member of the ubiquitin-conjugating enzyme family, plays a crucial role in the ubiquitin-proteasome system, which regulates protein degradation, signaling pathways, and various cellular processes. This enzyme facilitates the transfer of ubiquitin from an E1 ubiquitin-activating enzyme to target proteins, marking them for degradation or modulating their activity. Research has indicated that UBE2D4 is involved in various cellular functions, including DNA repair, cell cycle regulation, and response to stress, making it a focal point for understanding cellular homeostasis and disease mechanisms. Dysregulation of UBE2D4 has been implicated in numerous pathological conditions, including cancer, where altered ubiquitination processes contribute to tumor development and progression. Moreover, UBE2D4 has recently gained attention for its potential as a therapeutic target, as modulation of its activity can influence tumorigenesis and the efficacy of existing cancer treatments. Investigating UBE2D4’s structure, function, and interactions with other cellular proteins can provide deeper insights into its role in health and disease, opening avenues for the development of novel therapeutic strategies that harness the ubiquitin-proteasome system for clinical benefit. Overall, ongoing research into UBE2D4 holds promise for elucidating fundamental biological processes and advancing our understanding of the molecular underpinnings of various diseases, particularly in oncology and cellular stress responses.
