Analytical Data
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基因名
RAPGEF1
- Application
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别名
C3G; GRF2; RAP-GEF1; Guanine Nucleotide-Releasing Factor 2(Specific For Crk Proto-Oncogene); CRK SH3-binding GNRP
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种属
Human
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表达系统
E. coli
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标签
N-His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q13905
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表达区间
Lys780~Asn1035
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分子量
34kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
RAPGEF1, a member of the Ras activator protein family, plays a crucial role in cellular signaling pathways by activating the Ras subfamily of GTPases. It has been implicated in various physiological processes, including cell proliferation, differentiation, and survival. Research into RAPGEF1 is particularly relevant due to its involvement in several cancers and other diseases, where aberrant Ras signaling can contribute to tumorigenesis. The understanding of RAPGEF1's structure and function has been advanced through recombinant protein studies, which allow for the detailed analysis of its enzymatic activity and interaction with Ras proteins. Additionally, the generation of RAPGEF1 recombinant proteins enables researchers to explore its regulatory mechanisms and potential as a therapeutic target. Given its pivotal role in signaling cascades, RAPGEF1 is an attractive candidate for drug development, aiming to inhibit its activity or enhance its function in disease contexts. Overall, the study of RAPGEF1 and its recombinant forms is crucial for elucidating the complexities of Ras-mediated signaling and its implications in health and disease.
