Analytical Data
-
Gene name
EZR
- Application
-
Alternative Names
CVL; Ezrin; VIL2; CVIL; CVL; Villin 2; p81; Cytovillin
-
Species
Human
-
Source
E. coli
-
Tag
N-His
-
Purity
Greater than 90% as determined by SDS-PAGE.
-
Uniprot
P15311
-
Expression Region
Met1~Arg295
-
Molecular Weight
39kDa
-
Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
-
Form
Freeze-dried powder
-
Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
-
Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
EZR (Ezrin-Radixin-Moesin) is a member of the band 4.1 family of proteins, which play crucial roles in linking the plasma membrane to the cytoskeleton. Due to its pivotal involvement in cell signaling, adhesion, and migration, EZR is particularly significant in various physiological and pathological processes, including cancer metastasis and tissue morphogenesis. Research has shown that EZR is essential for the formation of membrane protrusions like microvilli and filopodia, making it important for maintaining cell shape and structural integrity. Additionally, its aberrant expression and activation have been implicated in several diseases, such as breast and colorectal cancers, where it can promote aggressive tumor behavior. The study of EZR's structural and functional properties, specifically its phosphorylation states and interactions with other cellular components, is vital for understanding how it influences cellular dynamics, tissue architecture, and signaling pathways. Investigating EZR's role through the development of recombinant proteins allows for a more comprehensive understanding of its functions and potential as a therapeutic target, particularly in cancer treatment, where modulation of its activity could inhibit tumor progression and metastasis. This line of research holds promise not only for advancing basic biological knowledge but also for contributing to novel strategies in disease management and therapeutic interventions.
