Analytical Data
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Gene name
CD1e
- Application
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Alternative Names
CD1-E; CD1-A; R2G1; T-Cell Surface Glycoprotein CD1e,Membrane-Associated
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Species
Human
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Source
E. coli
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Tag
N-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P15812
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Expression Region
Met39~Ala276
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Molecular Weight
29kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
CD1e is a member of the CD1 family of glycoproteins, which are critical for the presentation of lipid and glycolipid antigens to T cells. Unlike classical Major Histocompatibility Complex (MHC) molecules, which primarily present peptide antigens, CD1 molecules play a vital role in the immune response against lipid-rich pathogens, such as mycobacteria and certain fungi. The study of CD1e is particularly important because it has been implicated in autoimmune diseases and infections, where lipid antigens are involved. Researchers have observed that CD1e can interact with various lipid structures, influencing T cell activation and the subsequent immune response. However, the exact mechanisms of CD1e-mediated antigen presentation remain poorly understood, necessitating further exploration into its structural and functional properties. Recombinant CD1e proteins are being generated for high-resolution structural studies and functional assays to elucidate the binding affinities and specificities of various lipid ligands. This research holds potential for developing novel immunotherapeutic strategies by enhancing our understanding of lipid antigen recognition and its implications in health and disease. Thus, the investigation of CD1e recombinant proteins is a promising area in immunology, contributing to the broader knowledge of lipid antigen presentation and its role in shaping adaptive immune responses.
