Analytical Data
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Gene name
SMC3
- Application
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Alternative Names
BMH; BAM; CSPG6; HCAP; SMC3L1; Chondroitin Sulfate Proteoglycan 6; Bamacan; Basement membrane-associated chondroitin proteoglycan; Chromosome-associated peptide
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Species
Human
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Source
E. coli
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Tag
N-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9UQE7
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Expression Region
Ser994~Glu1181
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Molecular Weight
27kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
SMC3 (Structural Maintenance of Chromosomes 3) is a key protein within the SMC protein family, which plays a crucial role in the organization and segregation of chromosomes during cell division. Research on SMC3 has gained significant attention due to its involvement in the formation of cohesin complexes, which are essential for holding sister chromatids together after DNA replication and for facilitating proper chromosome alignment during mitosis and meiosis. Abnormalities in SMC3 function and cohesin dynamics have been linked to various genetic disorders, including cancer and developmental syndromes, emphasizing the importance of understanding its molecular mechanisms. The study of SMC3 has also been enriched by advances in structural biology techniques, allowing researchers to uncover the protein's three-dimensional structure and how it interacts with other cellular components. The exploration of SMC3’s role in gene regulation, DNA repair, and chromatin organization further highlights its importance in maintaining genomic stability. Current research is focused on uncovering therapeutic targets related to SMC3 and cohesin, potentially leading to novel interventions in diseases associated with chromosomal instability. Thus, the ongoing investigation of SMC3 not only enhances our understanding of cellular processes but also opens avenues for innovative treatments in the context of human health and disease.
