Analytical Data
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基因名
GLUT1
- Application
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别名
Glucose transporter type 1, erythrocyte/brain (GLUT-1) (HepG2 glucose transporter)
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种属
Human
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表达系统
E. coli
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标签
N- His & C- Myc
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P11166
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表达区间
207-271aa
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分子量
15.2 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
GLUT1, or glucose transporter type 1, is a pivotal membrane protein responsible for facilitating the transport of glucose across the plasma membranes of various cells, particularly in the brain and erythrocytes. Its crucial role in maintaining glucose homeostasis underscores its importance in metabolic processes. Mutations and dysregulation of GLUT1 have been implicated in several pathological conditions, such as GLUT1 deficiency syndrome, which leads to neurological disorders due to inadequate glucose supply to the brain. The study of recombinant GLUT1 proteins is essential for understanding its structure-function relationships, interactions with other cellular components, and regulatory mechanisms. Recent advancements in protein engineering and expression systems have enabled researchers to produce large quantities of functional GLUT1 for detailed investigations. Characterizing the protein through techniques such as crystallography, spectroscopy, and site-directed mutagenesis provides insights into its transport mechanism and potential therapeutic targets. As research continues, recombinant GLUT1 proteins not only enhance our comprehension of glucose transport physiology but may also foster the development of novel strategies for treating metabolic disorders.
