Analytical Data
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基因名
RABGEF1
- Application
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别名
RAP1Rabaptin-5-associated exchange factor for Rab5Rabex-5
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种属
Human
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表达系统
E. coli
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标签
N- His-SUMO
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9UJ41
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表达区间
1-491aa
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分子量
72.9 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
RABGEF1, a member of the RAB guanine nucleotide exchange factor (GEF) family, plays a crucial role in cellular processes by regulating the activity of RAB GTPases, which are key mediators of intracellular transport and signal transduction. The study of RABGEF1 is particularly relevant in the context of various diseases, including cancer and neurodegenerative disorders, where its dysregulation can disrupt normal cellular functions. Research has demonstrated that RABGEF1 can influence cellular signaling pathways, endocytosis, and exocytosis, thereby affecting cell proliferation, differentiation, and survival. Recent investigations have focused on the mechanisms through which RABGEF1 exerts its effects on RAB proteins, as well as its potential as a therapeutic target. Additionally, understanding the structural and functional characteristics of RABGEF1 through recombinant protein studies could provide valuable insights into its role in health and disease. This research could pave the way for developing novel strategies aimed at modulating RABGEF1 activity to restore normal cellular function in pathological conditions. Thus, RABGEF1 represents a significant focus of study in molecular biology and translational medicine, with promising implications for innovative therapeutic interventions.
