Analytical Data
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基因名
NUP35
- Application
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别名
MP44; NP44; Mitotic phosphoprotein 44; Nuclear pore complex protein Nup53
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种属
Human
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表达系统
E. coli
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标签
N-His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q8NFH5
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表达区间
Thr132~Lys310
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分子量
26kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
NUP35 is a critical component of the nuclear pore complex (NPC), which facilitates the bidirectional transport of molecules between the nucleus and the cytoplasm, thereby playing a vital role in cellular function and gene regulation. Recent studies have highlighted the significance of nuclear transport in various biological processes, including cell division, gene expression, and response to stress. Mutations or dysregulation of nucleoporins, including NUP35, have been implicated in several diseases, including cancer and neurodegenerative disorders. The study of recombinant NUP35 protein has gained attention as it allows researchers to investigate the structural and functional properties of this nucleoporin in vitro. By producing NUP35 as a recombinant protein, scientists can explore its binding interactions with other nucleoporins and nucleocytoplasmic transport receptors, providing deeper insights into the molecular mechanisms governing nucleocytoplasmic transport. Furthermore, understanding the dynamics of NUP35 may aid in the development of targeted therapeutic strategies aimed at diseases associated with nuclear transport dysfunction. Overall, research on recombinant NUP35 protein is advancing our knowledge of nuclear dynamics and its implications in health and disease.
