Analytical Data
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基因名
POLG2
- Application
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别名
DNA polymerase gamma accessory 55KDA subunit ;p55Mitochondrial DNA polymerase accessory subunitMtPolBPolG-beta
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种属
Human
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表达系统
E. coli
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标签
N- His-SUMO
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9UHN1
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表达区间
1-485aa
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分子量
70.9 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
POLG2, or polymerase gamma subunit 2, is a crucial component of the mitochondrial DNA polymerase complex, which plays a significant role in mitochondrial DNA replication and repair. The study of POLG2 is essential due to its involvement in various mitochondrial disorders, which can lead to conditions such as neurodegeneration, myopathy, and premature aging. Mutations in the POLG2 gene are associated with several human diseases, indicating its importance in maintaining mitochondrial function and cellular health. Research focused on recombinant POLG2 proteins aims to better understand the enzyme’s structure-function relationship and its interaction with other components of the mitochondrial DNA replication machinery. By producing and characterizing recombinant POLG2, scientists can explore its catalytic mechanisms, substrate specificity, and the effects of disease-linked mutations. This research not only elucidates the role of POLG2 in mitochondrial biology but also opens avenues for potential therapeutic interventions targeting mitochondrial dysfunction, highlighting the protein's significance in both basic and applied biomedical research. Understanding POLG2's function and regulation may pave the way for novel strategies to address mitochondrial diseases and enhance mitochondrial health, thus contributing to the broader field of mitochondrial medicine.
