Analytical Data
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Gene name
PTPRK
- Application
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Alternative Names
R-PTP-Kappa; PTPR-K; Protein-tyrosine phosphatase kappa
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Species
Human
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Source
E. coli
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Tag
N-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q15262
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Expression Region
Thr1185~Ser1440
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Molecular Weight
33kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
PTPRK, or Protein Tyrosine Phosphatase Receptor Type K, is a key enzyme involved in the regulation of various cellular processes, including cell proliferation, differentiation, and signaling pathways. Its role in dephosphorylating tyrosine residues on proteins makes it crucial for maintaining cellular homeostasis and responding to extracellular stimuli. Research has increasingly focused on PTPRK due to its implications in various diseases, particularly cancer, where dysregulation of tyrosine phosphorylation is a common feature. Studies have shown that PTPRK can act as a tumor suppressor in certain contexts, implicating its potential as a therapeutic target. Given the complexity of protein interactions and the need for precise regulation of signaling pathways, recombinant PTPRK proteins offer a valuable tool for elucidating its biological functions and mechanisms. By producing PTPRK in a recombinant system, researchers can obtain substantial quantities of the protein for extensive biochemical analyses and functional assays, thereby enhancing our understanding of its role in cellular signaling and disease pathology. This advancing research on PTPRK not only furthers our understanding of signal transduction mechanisms but also holds promise for the development of novel therapeutic strategies in cancer and other conditions associated with aberrant tyrosine phosphorylation.
