Analytical Data
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基因名
Cyclophilin B/PPIB
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简介
Cyclophilin B/PPIB protein is a peptidyl prolyl cis-trans isomerase (PPIase) that catalyzes the cis-trans isomerization of proline imide peptide bonds and may contribute to protein folding. This important enzymatic role highlights its importance in ensuring appropriate conformational changes in polypeptide chains, which are critical for functional maturation. Cyclophilin B/PPIB Protein, Human (HEK293, C-His, solution) is the recombinant human-derived Cyclophilin B/PPIB protein, expressed by HEK293 , with C-6*His labeled tag.
- Application
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别名
rHuPeptidyl-prolyl cis-trans isomerase B/PPIB, His; CYP-S1; CYPB; HEL-S-39; OI9; SCYLP
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种属
Human
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表达系统
HEK293
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标签
C-6*His
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纯度
Greater than 95% as determined by SDS-PAGE.
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蛋白编号
P23284
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表达区间
D34-A212
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蛋白长度
Full Length of Mature Protein
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分子量
21.0 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Cyclophilin B (CypB), encoded by the PPIB gene, is a peptidyl-prolyl cis-trans isomerase that plays a critical role in protein folding and cellular processes, such as signal transduction and immune response. Its involvement in several physiological and pathological conditions, including viral infections, cancer, and neurodegenerative diseases, has garnered significant research interest. Specifically, CypB has been identified as a crucial factor in HIV replication and is known to interact with viral proteins. The ability to produce recombinant CypB has advanced our understanding of its biological functions and interactions. By utilizing techniques such as recombinant DNA technology and mammalian expression systems, researchers can generate large quantities of CypB for structural and functional studies. These investigations have provided insights into the enzyme's catalytic mechanisms, its role in chaperoning proteins, and its potential as a therapeutic target. Moreover, recombinant CypB is used in drug screening assays and therapeutic interventions aimed at modulating its activity, which could lead to novel treatments for diseases associated with CypB dysfunction. Thus, the study of recombinant CypB remains a significant focus in molecular biology and pharmacology, promising advancements in medical applications through a deeper understanding of this versatile protein.
