Analytical Data
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基因名
COPS7A
- Application
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别名
Dermal papilla-derived protein 10JAB1-containing signalosome subunit 7a
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种属
Human
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表达系统
E. coli
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标签
N- His-SUMO
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9UBW8
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表达区间
2-275aa
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分子量
46.1 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
COPS7A is a member of the COP9 signalosome (CSN) complex, which plays a crucial role in various cellular processes, including protein degradation, cell cycle regulation, and gene expression. The CSN complex is composed of eight subunits, among which COPS7A is known for its deubiquitinating activity, critical for maintaining protein homeostasis and regulating signal transduction pathways. Research in recent years has highlighted the importance of COPS7A in various diseases, particularly cancer, where dysregulation of the CSN complex can lead to aberrant protein accumulation and tumorigenesis. Furthermore, studies have indicated that COPS7A may influence the stability of key oncogenes and tumor suppressors, thereby impacting cancer progression. Understanding the functional mechanisms of COPS7A, including its interactions with other cellular proteins and its role in the CSN complex, could provide valuable insights into targeted therapeutic strategies. The recombinant expression of COPS7A enables researchers to study its biochemical properties, structural characteristics, and potential interactions, facilitating the advancement of knowledge in cancer biology and therapeutic development. In summary, the research on COPS7A recombinant protein is pivotal for elucidating its role in cellular signaling pathways and its implications in cancer, paving the way for potential innovations in targeted cancer therapies.
