Analytical Data
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Gene name
HCAM
- Application
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Alternative Names
CDW44; CD44; CSPG8; ECMR-III; HCELL; IN; LHR; MC56; MDU2; MDU3; MIC4; MUTCH-I; Pgp1; Hematopoietic Cell E- And L-Selectin Ligand; Chondroitin Sulfate Proteoglycan 8
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Species
Human
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Source
E. coli
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Tag
N-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P16070
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Expression Region
Gln21~Gln320
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Molecular Weight
38kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
HCAM, or Human Cell Adhesion Molecule, is a type of transmembrane protein that plays a critical role in cell adhesion and signaling processes in various biological contexts. Research into HCAM has gained momentum due to its involvement in numerous physiological and pathological processes, including immune responses, tissue development, and cancer metastasis. The significance of HCAM is underscored by its interaction with other cell adhesion molecules and its contribution to the formation of specialized structures such as tight junctions. Moreover, aberrations in HCAM expression have been linked to several diseases, prompting scientists to investigate its potential as a therapeutic target and biomarker for disease diagnosis and prognosis. The recombinant production of HCAM protein provides a valuable tool for studying its structure-function relationships, cellular interactions, and mechanisms of action. Using techniques such as molecular cloning and protein expression systems, researchers aim to generate large quantities of functional HCAM for in vitro and in vivo studies. These studies not only enhance our understanding of HCAM's biological roles but also pave the way for the development of novel therapeutic strategies targeting cell adhesion processes in various diseases, including cancer and autoimmune disorders. Thus, the exploration of HCAM as a recombinant protein holds significant promise for advancing both basic and applied biomedical research.
