Analytical Data
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Gene name
DRD5
- Application
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Alternative Names
DR-D5; DBDR; DRD1B; DRD1L2; D1beta dopamine receptor
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Species
Human
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Source
E. coli
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Tag
N-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P21918
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Expression Region
Ala360~His477
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Molecular Weight
20kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Dopamine receptor D5 (DRD5) is a member of the dopamine receptor family, which plays a crucial role in the central nervous system by mediating dopamine signaling. Understanding the function and structure of DRD5 is essential due to its involvement in various neuropsychiatric disorders, including schizophrenia, addiction, and mood disorders. Recombination techniques have enabled researchers to produce recombinant DRD5 proteins, allowing for detailed studies of its pharmacological properties, signaling pathways, and potential therapeutic targets. The availability of recombinant DRD5 is particularly valuable for high-throughput screening of drug compounds and for elucidating the receptor's interactions with specific ligands. Furthermore, studying DRD5 can provide insights into its role in cognitive functions and behavior, as well as its unique interactions compared to other dopamine receptors. Overall, research on recombinant DRD5 not only advances our understanding of dopamine signaling dynamics but also opens new avenues for drug discovery and development aimed at treating dopamine-related disorders.
