Analytical Data
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Gene name
GATA3
- Application
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Alternative Names
HDR; Trans-acting T-cell-specific transcription factor GATA-3
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Species
Human
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Source
E. coli
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Tag
N-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P23771
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Expression Region
Tyr229~Gly444
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Molecular Weight
31kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
GATA3 is a crucial transcription factor that plays a significant role in various biological processes, particularly in the development and function of the immune system and several other tissues. It belongs to the GATA family of proteins, characterized by their zinc finger domains, which enable them to bind to specific DNA sequences and regulate gene expression. In the context of T-cell differentiation, GATA3 is essential for the development of Th2 cells, influencing the immune response to allergens and parasites. Abnormal GATA3 expression has been implicated in various diseases, including breast cancer, where it acts as a tumor suppressor and is associated with specific molecular subtypes of the disease. Given its pivotal role in health and disease, researchers have been keen to explore GATA3's structure and function through the study of recombinant GATA3 proteins. These studies aim to elucidate its mechanisms of action, regulatory networks, and potential therapeutic applications. By generating and characterizing recombinant GATA3, scientists can better understand its interactions with other proteins and its effects on cellular processes, paving the way for novel interventions in GATA3-related diseases.
