Analytical Data
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基因名
Des
- Application
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别名
CMD1I; CSM1; CSM2; Intermediate Filament Protein
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种属
Human
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表达系统
E. coli
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标签
N-His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P17661
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表达区间
Asp117~Gln348
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分子量
29kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Desmin is a type of intermediate filament protein that plays a crucial role in maintaining the structural integrity and function of skeletal and cardiac muscle cells. Research on desmin has gained significant attention due to its involvement in various myopathies and cardiomyopathies. Mutations in the desmin gene can lead to muscle dysfunction, progressive weakness, and heart failure. The understanding of desmin's role at the molecular level has important implications for developing therapeutic strategies for related diseases. Scientists have employed various biochemical and genetic approaches to study desmin's structure, assembly, and interactions with other cellular components. Recent advancements in techniques such as cryo-electron microscopy and advanced imaging have provided deeper insights into its organization within the muscle fibers. Additionally, studies have explored the potential of desmin as a biomarker for disease progression and therapeutic targets. Understanding the mechanisms underlying desmin-related disorders not only sheds light on muscle cell biology but also paves the way for innovative treatments aimed at enhancing muscle health and cardiac function.
