Analytical Data
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基因名
Menin
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简介
The Menin protein is an important component of the MLL/SET1 HMT complex, which methylates “Lys-4” of histone H3. It acts as a transcriptional regulator, inhibiting telomerase expression and inhibiting cell proliferation through TGFB1. Menin Protein, Human (His) is the recombinant human-derived Menin protein, expressed by E. coli , with N-6*His labeled tag.
- Application
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别名
MEN1; Menin
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种属
Human
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表达系统
E. coli
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标签
N-6*His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
O00255
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表达区间
M1-L615
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蛋白长度
Full Length
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分子量
68.9 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Menin is a protein encoded by the MEN1 gene, which plays a crucial role in endocrine tumorigenesis associated with Multiple Endocrine Neoplasia type 1 (MEN1) syndrome. The MEN1 gene mutation leads to the development of tumors in endocrine glands, including the pituitary gland, parathyroid gland, and pancreas. As a tumor suppressor, menin is involved in various cellular processes, including proliferation, apoptosis, and differentiation, as well as the regulation of gene expression through its interactions with chromatin and transcription factors. Research on menin has expanded in recent years, focusing on its dual role in both tumor suppression and potential oncogenic pathways. Studies have explored the molecular mechanisms underlying menin function, which include its interactions with histone methyltransferases and the epigenetic regulation of gene expression. Given its central role in endocrine tumor development, menin is a promising target for therapeutic interventions, particularly in the context of MEN1 syndrome. Additionally, understanding menin's function in cellular signaling pathways could provide insights into novel treatment strategies for other malignancies. The ongoing research aims to elucidate the precise mechanisms of menin action, explore its potential as a biomarker for tumor progression, and develop menin-targeted therapies that could improve patient outcomes in MEN1-related tumors and possibly other cancers.
