Analytical Data
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基因名
Sox2
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简介
Sox2 protein is a key transcription factor that forms a trimeric complex with OCT4 and controls the expression of genes critical for embryonic development (YES1, FGF4, UTF1, ZFP206). It binds the NANOG enhancer and is critical for early embryogenesis and stem cell pluripotency. Sox2 Protein, Human is the recombinant human-derived Sox2 protein, expressed by E. coli , with tag free.
- Application
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别名
SOX2; Transcription factor SOX-2
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种属
Human
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表达系统
E. coli
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标签
Tag Free
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P48431
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表达区间
R40-D123
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蛋白长度
Partial
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分子量
10.4 KDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Sox2, a member of the SRY-related HMG-box (Sox) transcription factor family, plays a crucial role in maintaining stem cell pluripotency and self-renewal, making it a significant focus in stem cell biology and regenerative medicine. Its expression is primarily observed in embryonic stem cells and certain adult stem cells, suggesting a pivotal function in early development and tissue homeostasis. Research has shown that Sox2 collaborates with other transcription factors, such as Oct4 and Nanog, to form a core regulatory network essential for maintaining the undifferentiated state of stem cells. Moreover, Sox2's involvement in cellular reprogramming has made it a key component in generating induced pluripotent stem cells (iPSCs) from somatic cells, which has implications for both disease modeling and therapeutic applications. The study of recombinant Sox2 protein is critical for deciphering its mechanisms of action and interactions at the molecular level. By producing and characterizing Sox2 as a recombinant protein, researchers can investigate its structural properties, binding affinities, and functional interactions with other proteins and DNA. This knowledge is vital for understanding the role of Sox2 in stem cell biology and its potential manipulation in regenerative therapies. Furthermore, exploring Sox2's role in various pathological conditions, such as cancer, offers insights into its potential as a therapeutic target or biomarker. Consequently, the investigation of recombinant Sox2 protein forms the cornerstone of fundamental and applied research aimed at harnessing the power of stem cells for innovative medical solutions.
