Analytical Data
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Gene name
ACSS1
- Application
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Alternative Names
ACAS2L; Acetate CoA ligase 2; Acetate--CoA ligase 2
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Species
Human
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Source
P. pastoris
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Tag
N-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9NUB1-1
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Expression Region
A38-K689
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AA Sequence
ASGPSGSAPAVAAAAAQPGSYPALSAQAAREPAAFWGPLARDTLVWDTPYHTVWDCDFSTGKIGWFLGGQLNVSVNCLDQHVRKSPESVALIWERDEPGTEVRITYRELLETTCRLANTLKRHGVHRGDRVAIYMPVSPLAVAAMLACARIGAVHTVIFAGFSAESLAGRINDAKCKVVITFNQGLRGGRVVELKKIVDEAVKHCPTVQHVLVAHRTDNKVHMGDLDVPLEQEMAKEDPVCAPESMGSEDMLFMLYTSGSTGMPKGIVHTQAGYLLYAALTHKLVFDHQPGDIFGCVADIGWITGHSYVVYGPLCNGATSVLFESTPVYPNAGRYWETVERLKINQFYGAPTAVRLLLKYGDAWVKKYDRSSLRTLGSVGEPINCEAWEWLHRVVGDSRCTLVDTWWQTETGGICIAPRPSEEGAEILPAMAMRPFFGIVPVLMDEKGSVVEGSNVSGALCISQAWPGMARTIYGDHQRFVDAYFKAYPGYYFTGDGAYRTEGGYYQITGRMDDVINISGHRLGTAEIEDAIADHPAVPESAVIGYPHDIKGEAAFAFIVVKDSAGDSDVVVQELKSMVATKIAKYAVPDEILVVKRLPKTRSGKVMRRLLRKIITSEAQELGDTTTLEDPSIIAEILSVYQKCKDKQAAAK
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Protein Length
Full Length of Isoform-1 Mature Protein
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
ACSS1 (Acetyl-CoA Synthetase 1) is a key enzyme involved in the conversion of acetate into acetyl-CoA, a central metabolite in cellular energy metabolism and biosynthetic pathways. Recent studies have highlighted the significance of ACSS1 in various physiological processes, including fatty acid synthesis, energy homeostasis, and tumorigenesis. Dysregulation of ACSS1 has been implicated in metabolic disorders, such as obesity and diabetes, as well as in cancer progression by providing acetyl-CoA for biosynthetic demands of rapidly proliferating cells. Given its pivotal role, ACSS1 has garnered attention as a potential therapeutic target. Research has focused on understanding its structure, function, and regulatory mechanisms, with the aim of developing inhibitors that could modulate its activity for clinical applications. Furthermore, recent advancements in recombinant protein technology have enabled the production of ACSS1 to facilitate detailed biochemical and structural studies. Investigating the recombinant ACSS1 protein will not only enhance our understanding of its biochemical properties and interactions but also pave the way for novel strategies in the treatment of metabolic diseases and cancer. Overall, the study of ACSS1 is a promising area of research that bridges basic science and therapeutic development, with the potential to significantly impact public health.
