Analytical Data
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Gene name
SPLUNC2
- Application
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Alternative Names
BPIFA2; PSP; C20orf70; BPI fold-containing family A member 2; Parotid secretory protein
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Species
Human
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Source
HEK293
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Tag
N-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q96DR5
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Expression Region
Glu19~Ile249
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Molecular Weight
35kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
SPLUNC2 (Short palate, lung, and nasal epithelium clone 2) is a protein primarily expressed in the respiratory and nasal epithelia, where it plays a crucial role in innate immunity and mucosal defense. It is part of the broader SPLUNC family, which is known for its involvement in maintaining airway homeostasis and regulating inflammatory responses. Recent studies have highlighted SPLUNC2's various functions, including antibacterial activity, modulation of mucin secretion, and protective roles against respiratory pathogens, suggesting its potential as a biomarker for respiratory diseases such as asthma and chronic obstructive pulmonary disease (COPD). Given its diverse functions and involvement in epithelial barrier integrity, researchers are increasingly focused on understanding the molecular mechanisms underlying SPLUNC2's activity. This includes examining the protein's structure-function relationship, its interactions with other biomolecules, and its regulatory pathways. The recombinant expression of SPLUNC2 can facilitate the investigation of its biological properties and therapeutic potential. By producing large quantities of the protein, researchers aim to conduct functional assays and elucidate its role in inflammation and host defense mechanisms. Additionally, SPLUNC2's potential as a therapeutic target or biomarker has drawn attention in the context of developing novel treatments for respiratory conditions, emphasizing the importance of ongoing research into this multifaceted protein. Overall, the study of SPLUNC2 not only contributes to our understanding of respiratory biology but also paves the way for innovative approaches to combat respiratory diseases.
