Analytical Data
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基因名
MCAK
- Application
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别名
KIF2C; KNSL6; Kinesin Family Member 2C; Kinesin-Like 6
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种属
Human
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表达系统
HEK293
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标签
N-His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q99661
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表达区间
Ala2~Gln725
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分子量
83kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
MCAK, or Mitotic Centromere-Associated Kinesin, is a member of the kinesin superfamily of motor proteins, primarily known for its role in the regulation of microtubule dynamics during cell division. Research on MCAK has gained significant attention due to its essential function in mitosis and its implication in various diseases, including cancer. The protein acts as a depolymerase that regulates the stability of microtubules at the centromere, facilitating the proper segregation of chromosomes during cell division. Dysregulation of MCAK can lead to chromosome misalignment and aneuploidy, which are common features in tumorigenesis. Understanding the structural and functional properties of MCAK reconstituted as a recombinant protein presents opportunities for elucidating its molecular mechanisms and interactions with other cellular components. Such studies are crucial for developing targeted therapies aimed at modulating MCAK activity, thereby enhancing the efficacy of cancer treatment. The advancements in recombinant protein technology enable detailed investigations into MCAK's role in cell cycle regulation, making it a pivotal subject in cancer research and therapeutic development.
