Recombinant Human ERCC1 Protein(HEK293)，His

ERCC1 (Excision Repair Cross-Complementation Group 1) is a critical protein involved in the nucleotide excision repair (NER) pathway, which is essential for the repair of DNA damage caused by various environmental factors, such as UV radiation and chemical agents. Mutations or dysfunctions in ERCC1 can lead to increased susceptibility to DNA damage and contribute to the development of various diseases, including cancer and genetic disorders like Xeroderma Pigmentosum. Moreover, ERCC1 plays a significant role in the repair of interstrand crosslinks, making it vital for maintaining genomic stability. Recent research has focused on the role of ERCC1 as a potential biomarker for predicting the efficacy of chemotherapy and radiotherapy, particularly in cancers such as non-small cell lung cancer (NSCLC) and ovarian cancer. Studies have shown that high levels of ERCC1 expression are associated with resistance to platinum-based therapies, leading to the investigation of ERCC1 inhibitors as a promising approach to sensitize tumors and enhance treatment outcomes. Additionally, understanding the molecular mechanisms that regulate ERCC1 expression and its interaction with other repair proteins can provide insights into novel therapeutic targets. This growing body of research underscores the importance of ERCC1 not only in DNA repair but also in clinical applications, paving the way for improved strategies in cancer treatment and management.