Analytical Data
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基因名
CLIC3
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简介
The CLIC3 protein is a multifunctional molecule capable of integrating into membranes and forming chloride channels. It has been implicated in potential roles related to cell growth control. CLIC3 Protein, Human (His) is the recombinant human-derived CLIC3 protein, expressed by E. coli , with C-6*His labeled tag.
- Application
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别名
rHuChloride intracellular channel protein 3/CLIC3, His; Chloride intracellular channel protein 3; CLIC3
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种属
Human
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表达系统
E. coli
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标签
C-6*His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
O95833
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表达区间
M1-R236
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氨基酸序列
MAETKLQLFVKASEDGESVGHCPSCQRLFMVLLLKGVPFTLTTVDTRRSPDVLKDFAPGSQLPILLYDSDAKTDTLQIEDFLEETLGPPDFPSLAPRYRESNTAGNDVFHKFSAFIKNPVPAQDEALYQQLLRALARLDSYLRAPLEHELAGEPQLRESRRRFLDGDRLTLADCSLLPKLHIVDTVCAHFRQAPIPAELRGVRRYLDSAMQEKEFKYTCPHSAEILAAYRPAVHPR
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蛋白长度
Full Length
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分子量
31 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CLIC3, a member of the chloride intracellular channel (CLIC) protein family, has garnered attention due to its pivotal role in various cellular processes, including regulation of ion transport, cell proliferation, and apoptosis. The protein is known to be involved in maintaining cellular homeostasis and has been implicated in several pathophysiological conditions, including cancer and neurodegenerative diseases. Research into CLIC3 often focuses on its unique mechanism of action, which differentiates it from other ion channels; it can exist in both soluble and membrane-bound forms, suggesting versatile roles in cellular signaling. The reconstitution of CLIC3 into cell membranes is essential for elucidating its functional properties and understanding its regulatory mechanisms in physiological and pathological contexts. By employing techniques such as recombinant protein expression and purification, scientists aim to produce functional CLIC3 proteins for detailed biophysical and biochemical studies. This research is crucial not only for understanding the fundamental biology of CLIC3 but also for exploring its potential as a therapeutic target. Continued investigation into the role of CLIC3 in cellular processes could provide new insights into treatment strategies for diseases where ion imbalance plays a critical role.
