Analytical Data
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Gene name
Periostin
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简介
Periostin protein is a multifunctional molecule that plays a key role in cellular processes by inducing cell attachment and spreading, emphasizing its importance in cell adhesion dynamics. Furthermore, Periostin contributes to the structural integrity of connective tissue by enhancing the binding of BMP1 to the fibronectin matrix and promoting subsequent proteolytic activation of lysyl oxidase LOX. Periostin Protein, Mouse (Q62009-2, HEK293, His) is the recombinant mouse-derived Periostin protein, expressed by HEK293 , with C-His labeled tag.
- Application
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Alternative Names
Periostin; PN; OSF-2; POSTN; OSF2; Fasciclin I-like; PDLPOSTN; PNRP11-412K4.1; TRIF52
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Species
Mouse
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Source
HEK293
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Tag
C-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q62009-2
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Expression Region
N24-Q811
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Protein Length
Partial
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Molecular Weight
90-95 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Periostin, a matricellular protein, plays a crucial role in various biological processes, including tissue development, repair, and inflammatory responses. Initially identified as a key component of the periosteum, its expression has been observed in numerous tissues, particularly during embryogenesis and in response to injury. Research has indicated that periostin is involved in cell adhesion, migration, and survival, mediated through its interactions with integrins and other extracellular matrix components. This protein has garnered significant attention in the context of several diseases, including fibrosis, cardiovascular disorders, and cancer, where its upregulation correlates with disease progression and poor prognosis. The recombinant form of periostin has emerged as a valuable tool for studying its functional roles in vitro and in vivo, enabling researchers to dissect its mechanistic pathways and therapeutic potentials. Additionally, periostin's role as a biomarker for certain conditions has prompted investigations into its utility in clinical settings, paving the way for novel diagnostic and therapeutic strategies. The ongoing research into periostin's biological functions underscores its significance in health and disease, emphasizing the necessity for further exploration of this versatile protein and its potential applications in regenerative medicine and targeted therapies.
