Analytical Data
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Gene name
NTS
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简介
NTS1/NTSR1, the neurotensin receptor 1, potentially regulates fat metabolism through endocrine or paracrine mechanisms. Interacting with its ligand, neurotensin, NTS1/NTSR1 induces smooth muscle contraction. The receptor's interactions with neurotensin and other proteins like SORT1 and SORL1 suggest involvement in diverse cellular processes, indicating potential implications for fat metabolism regulation. NTS Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived NTS protein, expressed by HEK293, with C-hFc labeled tag.
- Application
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Alternative Names
neuromedin N; neurotensin/neuromedin N
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Species
Mouse
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Source
HEK293
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Tag
C-hFc
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9D3P9
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Expression Region
S23-L162
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Protein Length
Partial
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Molecular Weight
48-53 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
NTS (Neuropeptide S) is a neuropeptide that plays a crucial role in the regulation of various physiological functions, including stress response, anxiety, and sleep modulation. Its discovery has garnered significant interest due to its potential implications in understanding anxiety disorders and depression. Research into NTS has highlighted its receptor interactions and the pathways it influences, which involve multiple neurotransmitter systems. The functional characterization of NTS-derived recombinant proteins offers valuable insights into their biological activities and therapeutic potential. Through the use of recombinant DNA technology, scientists can produce NTS proteins in a controlled environment, allowing for in-depth studies of their mechanisms of action. This research is pivotal as it paves the way for developing novel treatment strategies for mental health disorders. Additionally, understanding the structure-function relationships of NTS can aid in the design of more effective therapeutic agents that target specific receptor subtypes, potentially minimizing side effects associated with traditional medications. As such, ongoing studies focused on the recombinant expression and functional assays of NTS are essential for elucidating its role in neurobiology and advancing pharmacological applications.
