Analytical Data
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基因名
PTPMT1
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简介
The PTPMT1 protein is a lipid phosphatase that critically regulates cellular lipid metabolism by dephosphorylating phosphatidylglycerolphosphate (PGP) to form phosphatidylglycerol (PG). This step is critical for the biosynthesis of cardiolipin, a key mitochondrial phospholipid that regulates membrane integrity and mitochondrial activity. PTPMT1 Protein, Human (His) is the recombinant human-derived PTPMT1 protein, expressed by E. coli , with N-His labeled tag.
- Application
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别名
Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1; PTPMT1; MOSP; PLIP
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种属
Human
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表达系统
E. coli
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标签
N-His
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纯度
Greater than 95% as determined by SDS-PAGE.
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蛋白编号
Q8WUK0-1
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表达区间
K28-T201
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蛋白长度
Full Length of Isoform-1 Mature Protein
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分子量
22 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
PTPMT1 (Protein Tyrosine Phosphatase Methylesterase 1) is an important enzyme involved in various cellular processes, including signaling pathways related to cell growth, differentiation, and metabolism. Its role in the regulation of protein tyrosine phosphorylation makes it a significant target for understanding the intricacies of cellular signaling networks. The aberrant expression or dysfunction of PTPMT1 has been implicated in several diseases, including cancer and metabolic disorders, highlighting its potential as a biomarker and therapeutic target. Research into the recombinant expression of PTPMT1 aids in the elucidation of its structure-function relationship and facilitates the development of inhibitors that can modulate its activity. Recombinant proteins allow for detailed studies of enzymatic mechanisms and interactions with other cellular components, providing insights that may lead to novel therapeutic strategies. Additionally, understanding the regulation of PTPMT1 can pave the way for interventions aimed at restoring normal cellular function in disease states. As a result, the study of PTPMT1 is crucial not only for basic biomedical research but also for the development of targeted therapies in clinical settings.
