Analytical Data
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基因名
Somatostatin R1/SSR1
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简介
The somatostatin R1 (SSR1) protein contains TRAP-α, TRAP-β, TRAP-δ, and TRAP-gamma, forming a heterotetramer. They play a role in binding calcium to the ER membrane and regulating the retention of ER-resident proteins. Somatostatin R1/SSR1 Protein, Human (HEK293, Fc) is the recombinant human-derived Somatostatin R1/SSR1 protein, expressed by HEK293 , with C-hFc labeled tag.
- Application
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别名
Translocon-associated protein subunit alpha; TRAP-alpha; SSR-alpha; TRAPA; PSEC0262
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种属
Human
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表达系统
HEK293
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标签
C-hFc
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纯度
Greater than 95% as determined by SDS-PAGE.
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蛋白编号
P43307-1
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表达区间
V19-T207
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氨基酸序列
VLFRGGPRGLLAVAQDLTEDEETVEDSIIEDEDDEAEVEEDEPTDLVEDKEEEDVSGEPEASPSADTTILFVKGEDFPANNIVKFLVGFTNKGTEDFIVESLDASFRYPQDYQFYIQNFTALPLNTVVPPQRQATFEYSFIPAEPMGGRPFGLVINLNYKDLNGNVFQDAVFNQTVTVIEREDGLDGET
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蛋白长度
Lumenal Domain
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分子量
55-75 kDa.
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Somatostatin receptors (SSTRs) are a family of G protein-coupled receptors that bind somatostatin, a peptide hormone involved in the regulation of various physiological processes such as hormone secretion, cell proliferation, and neurotransmission. Among the five subtypes of somatostatin receptors, Somatostatin R1 (SSR1) plays a crucial role in modulating the activity of endocrine and exocrine tissues. Research on SSR1 has gained prominence due to its implications in several pathological conditions, including neuroendocrine tumors, diabetes, and disorders related to the central nervous system. The interest in SSR1 has been further heightened by its potential as a therapeutic target for drug development. The reconstitution of SSR1 proteins through recombinant DNA technology enables the study of their function, signaling pathways, and interactions with ligands. By producing SSR1 as a recombinant protein, researchers can facilitate high-throughput screening of pharmacological agents, elucidate the receptor's structural properties, and explore its role in various signaling cascades. The understanding of SSR1 and its mechanisms can lead to novel therapeutic strategies for diseases linked to somatostatin dysregulation and enhance our comprehension of somatostatin’s diverse biological effects.
