Analytical Data
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Gene name
Somatostatin R1/SSR1
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简介
The somatostatin R1 (SSR1) protein contains TRAP-α, TRAP-β, TRAP-δ, and TRAP-gamma, forming a heterotetramer. They play a role in binding calcium to the ER membrane and regulating the retention of ER-resident proteins. Somatostatin R1/SSR1 Protein, Human (HEK293, Fc) is the recombinant human-derived Somatostatin R1/SSR1 protein, expressed by HEK293 , with C-hFc labeled tag.
- Application
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Alternative Names
Translocon-associated protein subunit alpha; TRAP-alpha; SSR-alpha; TRAPA; PSEC0262
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Species
Human
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Source
HEK293
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Tag
C-hFc
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Purity
Greater than 95% as determined by SDS-PAGE.
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Uniprot
P43307-1
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Expression Region
V19-T207
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AA Sequence
VLFRGGPRGLLAVAQDLTEDEETVEDSIIEDEDDEAEVEEDEPTDLVEDKEEEDVSGEPEASPSADTTILFVKGEDFPANNIVKFLVGFTNKGTEDFIVESLDASFRYPQDYQFYIQNFTALPLNTVVPPQRQATFEYSFIPAEPMGGRPFGLVINLNYKDLNGNVFQDAVFNQTVTVIEREDGLDGET
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Protein Length
Lumenal Domain
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Molecular Weight
55-75 kDa.
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Somatostatin receptors (SSTRs) are a family of G protein-coupled receptors that bind somatostatin, a peptide hormone involved in the regulation of various physiological processes such as hormone secretion, cell proliferation, and neurotransmission. Among the five subtypes of somatostatin receptors, Somatostatin R1 (SSR1) plays a crucial role in modulating the activity of endocrine and exocrine tissues. Research on SSR1 has gained prominence due to its implications in several pathological conditions, including neuroendocrine tumors, diabetes, and disorders related to the central nervous system. The interest in SSR1 has been further heightened by its potential as a therapeutic target for drug development. The reconstitution of SSR1 proteins through recombinant DNA technology enables the study of their function, signaling pathways, and interactions with ligands. By producing SSR1 as a recombinant protein, researchers can facilitate high-throughput screening of pharmacological agents, elucidate the receptor's structural properties, and explore its role in various signaling cascades. The understanding of SSR1 and its mechanisms can lead to novel therapeutic strategies for diseases linked to somatostatin dysregulation and enhance our comprehension of somatostatin’s diverse biological effects.
