Analytical Data
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基因名
Carbonic Anhydrase VIII/CA8
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简介
Despite its name, the carbonic anhydrase VIII (CA8) protein lacks carbonic anhydrase catalytic activity. This distinguishes CA8 from its typical functions related to carbonic anhydrase, an enzyme known for its ability to catalyze the reversible hydration of carbon dioxide. Carbonic Anhydrase VIII/CA8 Protein, Mouse (His) is the recombinant mouse-derived Carbonic Anhydrase VIII/CA8 protein, expressed by E. coli , with C-His labeled tag.
- Application
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别名
Carbonic Anhydrase-Related Protein; CARP; Carbonic Anhydrase VIII; CA8; CALS
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种属
Mouse
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表达系统
E. coli
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标签
C-6*His
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纯度
Greater than 95% as determined by SDS-PAGE.
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蛋白编号
P28651
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表达区间
M1-Q291
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氨基酸序列
MADLSFIEDAVAFPEKEEDEEEEEEEGVEWGYEEGVEWGLVFPDANGEYQSPINLNSREARYDPSLLDVRLSPNYVVCRDCEVTNDGHTIQVILKSKSVLSGGPLPQGQEFELYEVRFHWGRENQRGSEHTVNFKAFPMELHLIHWNSTLFGSIDEAVGKPHGIAIIALFVQIGKEHVGLKAVTEILQDIQYKGKSKTIPCFNPNTLLPDPLLRDYWVYEGSLTIPPCSEGVTWILFRYPLTISQMQIEEFRRLRTHVKGAELVEGCDGILGDNFRPTQPLSDRVIRAAFQ
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蛋白长度
Full Length
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分子量
35 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Carbonic Anhydrase VIII (CA8) is a member of the carbonic anhydrase enzyme family, which plays a critical role in regulating acid-base homeostasis and facilitating various physiological processes by catalyzing the reversible conversion of carbon dioxide and water to bicarbonate and protons. CA8 is predominantly expressed in the brain and has been implicated in neuronal signaling, synaptic transmission, and possibly the modulation of respiratory functions. Its dysfunction or altered expression levels are associated with several neurological disorders, including epilepsy and various neurodegenerative diseases. Research on recombinant CA8 protein has gained momentum as scientists aim to elucidate its specific biochemical properties, catalytic mechanisms, and physiological roles. Producing recombinant CA8 allows for detailed structural and functional analyses, paving the way for potential therapeutic applications targeting neurological conditions. Furthermore, understanding CA8's involvement in ion transport and its interaction with other cellular components may provide insights into its unique role in brain physiology and pathology. Overall, the study of recombinant CA8 protein is essential for developing novel strategies for diagnosing and treating related disorders, making it a significant focus within the fields of biochemistry, neurobiology, and molecular medicine.
