Analytical Data
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Gene name
TXNL4B
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简介
TXNL4B Protein, vital for pre-mRNA splicing, is crucial for S/G(2) cell cycle transition, forming homodimers and interacting with the U5-102 kDa spliceosome subunit. It plays a key role in splicing intricacies and influences cell cycle dynamics. TXNL4B Protein, Human (His) is the recombinant human-derived TXNL4B protein, expressed by E. coli , with N-His labeled tag.
- Application
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Alternative Names
Thioredoxin-like protein 4B; Dim1-like protein; DIM2; DLP
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Species
Human
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Source
E. coli
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Tag
N-His
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Purity
Greater than 95% as determined by SDS-PAGE.
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Uniprot
Q9NX01
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Expression Region
M1-I149
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Protein Length
Full Length
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Molecular Weight
19 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
TXNL4B, or Thioredoxin-like protein 4B, is a member of the thioredoxin family, which is known for its role in redox signaling and cellular stress responses. Recent studies have suggested that TXNL4B plays a critical role in various biological processes, including cell proliferation, apoptosis, and the regulation of gene expression. This protein has garnered attention due to its potential involvement in cancer biology, particularly in how it influences the tumor microenvironment and the sensitivity of cancer cells to chemotherapy. Research indicates that TXNL4B might interact with key oncogenic pathways, making it a candidate for novel therapeutic strategies. Moreover, the capacity of TXNL4B to act as an antioxidant and its influence on protein folding further emphasize its importance in maintaining cellular homeostasis. As a result, the recombinant expression of TXNL4B has become a focal point for investigations aimed at elucidating its functional mechanisms and potential as a biomarker or therapeutic target in diseases characterized by oxidative stress and deregulated redox homeostasis. Understanding the properties and interactions of this protein could provide critical insights into its role in both normal physiology and disease pathology. The ongoing research into the recombinant form of TXNL4B aims to create more advanced experimental models, facilitating the exploration of its functions and the development of targeted interventions in cancer and other related conditions.
