Analytical Data
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基因名
Kallikrein-13
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简介
Kallikrein-13 (KLK13) is a member of KLK family and is a secreted serine protease expressed in endocrine tissues, including the prostate, testis, breast, and ovary.Expression of KLK13 is regulated by steroid hormones and may be useful as a marker for breast cancer.KLK13 is also required for the human coronavirus HKU1 infection of human respiratory epithelial cells as a priming protease.Kallikrein-13 Protein, Human (HEK293, His) is the recombinant human-derived Kallikrein-13 protein, expressed by HEK293 , with C-6*His labeled tag.
- Application
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别名
Kallikrein-13; Kallikrein-Like Protein 4; KLK-L4; KLK13; KLKL4
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种属
Human
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表达系统
HEK293
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标签
C-6*His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9UKR3
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表达区间
G17-I262
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氨基酸序列
GGVSQESSKVLNTNGTSGFLPGGYTCFPHSQPWQAALLVQGRLLCGGVLVHPKWVLTAAHCLKEGLKVYLGKHALGRVEAGEQVREVVHSIPHPEYRRSPTHLNHDHDIMLLELQSPVQLTGYIQTLPLSHNNRLTPGTTCRVSGWGTTTSPQVNYPKTLQCANIQLRSDEECRQVYPGKITDNMLCAGTKEGGKDSCEGDSGGPLVCNRTLYGIVSWGDFPCGQPDRPGVYTRVSRYVLWIRETI
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蛋白长度
Partial
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分子量
28-38 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Kallikrein-13 (KLK13), a member of the kallikrein family of serine proteases, has garnered attention due to its potential roles in various physiological and pathological processes, including cancer progression and metastasis. This enzyme, also known as human glandular kallikrein 13 (hK13), is implicated in the regulation of extracellular matrix components and activation of other proteases, suggesting a key function in tissue remodeling. Elevated levels of KLK13 have been observed in several malignancies, particularly ovarian cancer, where it is associated with poor prognosis. The study of KLK13 has been further motivated by its potential as a diagnostic biomarker and therapeutic target. The recombinant expression of KLK13 enables detailed investigations into its biological functions, substrate specificity, and interaction with other proteins. Understanding KLK13's mechanisms can provide insights into disease processes and pave the way for the development of innovative therapeutic strategies. Researchers are actively exploring the biochemical properties and clinical implications of KLK13, focusing on its role in cancer diagnostics and targeted therapies, which could lead to improved patient outcomes.
