Analytical Data
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Gene name
TPPP3
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简介
The TPPP3 protein is a microtubule-associated regulator that exerts a critical influence on microtubule dynamics through bundling activity. Its important role extends to embryonic implantation and decidualization, implicated in reproductive events. TPPP3 Protein, Human (His) is the recombinant human-derived TPPP3 protein, expressed by E. coli , with N-His labeled tag.
- Application
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Alternative Names
Tubulin polymerization-promoting protein family member 3; TPPP/p20; CGI-38
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Species
Human
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Source
E. coli
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Tag
N-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9BW30
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Expression Region
M1-K176
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Protein Length
Full Length
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Molecular Weight
19 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
TPPP3 (Tubulin Polymerization Promoting Protein 3) is a member of the TPPP family, known for its role in promoting the polymerization of tubulin, a fundamental structural protein in cells. Research on TPPP3 has garnered attention due to its potential implications in various physiological and pathological processes, including neurodegenerative diseases and cancer. The protein is primarily expressed in the brain, where it is associated with the regulation of microtubule dynamics, critical for maintaining neuronal structure and function. Studies have shown that alterations in TPPP3 expression can impact neuronal survival and are linked to conditions such as Alzheimer's disease and multiple sclerosis. Additionally, TPPP3 has been implicated in the proliferation and migration of cancer cells, suggesting its involvement in tumorigenesis. Understanding the molecular mechanisms by which TPPP3 influences microtubule assembly and stability can provide insights into these diseases and potentially lead to the development of therapeutic strategies. As such, the study of TPPP3 and its recombinant forms is essential for elucidating its biological roles and therapeutic potential in treating disorders associated with microtubule dysregulation.
