Analytical Data
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Gene name
TMUB2
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简介
TMUB2 Protein is a poorly characterized TMUB1 paralog. TMUB2 is a part of various ERAD complexes. In addition, it is a component of the membrane that has transmembrane function. TMUB2 is related to TP53 protein expression. TMUB2 expression increases with age in skin, adipose tissue, blood, and brain and is associated with cancer initiation and progression. TMUB2 Protein, Human (HEK293, His) is the recombinant human-derived TMUB2 protein, expressed by HEK293 , with N-His labeled tag.
- Application
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Alternative Names
Transmembrane and ubiquitin-like domain-containing protein 2; TMUB2
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Species
Human
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Source
HEK293
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Tag
N-His
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Purity
Greater than 95% as determined by SDS-PAGE.
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Uniprot
Q71RG4-2
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Expression Region
Y37-S245
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AA Sequence
YVADSGSNQLLGAIVSAGDTSVLHLGHVDHLVAGQGNPEPTELPHPSEGNDEKAEEAGEGRGDSTGEAGAGGGVEPSLEHLLDIQGLPKRQAGAGSSSPEAPLRSEDSTCLPPSPGLITVRLKFLNDTEELAVARPEDTVGALKSKYFPGQESQMKLIYQGRLLQDPARTLRSLNITDNCVIHCHRSPPGSAVPGPSASLAPSATEPPS
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Protein Length
Partial
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Molecular Weight
43 kDa due to glycosylation
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
TMUB2, or Tumor Membrane Protein 2, is an important protein involved in various cellular processes, including apoptosis, cell proliferation, and stress response. Studies have shown that TMUB2 plays a significant role in the degradation of misfolded proteins, serving as a co-chaperone that assists in the proper folding and management of cellular proteins, particularly under stress conditions. The dysregulation of TMUB2 expression has been implicated in various diseases, including cancer, where it may contribute to tumor progression and resistance to therapies. Researchers are increasingly focused on understanding the molecular mechanisms by which TMUB2 influences cellular homeostasis and its potential as a therapeutic target. Recombinant TMUB2 protein studies allow for the detailed investigation of its structural and functional properties, facilitating the exploration of its interactions with other proteins and its role in relevant signaling pathways. Insights gained from such research could provide valuable information for the development of novel therapeutic strategies aimed at modulating TMUB2 activity in disease contexts. Moreover, as TMUB2 is expressed in various tissues, its study could have implications beyond oncology, extending to neurodegenerative diseases and metabolic disorders. Overall, understanding TMUB2's function and regulation may unveil new avenues for targeted therapies and contribute to a broader comprehension of cellular stress responses and protein homeostasis in health and disease.
