Analytical Data
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基因名
TMUB2
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简介
TMUB2 Protein is a poorly characterized TMUB1 paralog. TMUB2 is a part of various ERAD complexes. In addition, it is a component of the membrane that has transmembrane function. TMUB2 is related to TP53 protein expression. TMUB2 expression increases with age in skin, adipose tissue, blood, and brain and is associated with cancer initiation and progression. TMUB2 Protein, Human (HEK293, His) is the recombinant human-derived TMUB2 protein, expressed by HEK293 , with N-His labeled tag.
- Application
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别名
Transmembrane and ubiquitin-like domain-containing protein 2; TMUB2
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种属
Human
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表达系统
HEK293
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标签
N-His
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纯度
Greater than 95% as determined by SDS-PAGE.
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蛋白编号
Q71RG4-2
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表达区间
Y37-S245
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氨基酸序列
YVADSGSNQLLGAIVSAGDTSVLHLGHVDHLVAGQGNPEPTELPHPSEGNDEKAEEAGEGRGDSTGEAGAGGGVEPSLEHLLDIQGLPKRQAGAGSSSPEAPLRSEDSTCLPPSPGLITVRLKFLNDTEELAVARPEDTVGALKSKYFPGQESQMKLIYQGRLLQDPARTLRSLNITDNCVIHCHRSPPGSAVPGPSASLAPSATEPPS
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蛋白长度
Partial
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分子量
43 kDa due to glycosylation
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
TMUB2, or Tumor Membrane Protein 2, is an important protein involved in various cellular processes, including apoptosis, cell proliferation, and stress response. Studies have shown that TMUB2 plays a significant role in the degradation of misfolded proteins, serving as a co-chaperone that assists in the proper folding and management of cellular proteins, particularly under stress conditions. The dysregulation of TMUB2 expression has been implicated in various diseases, including cancer, where it may contribute to tumor progression and resistance to therapies. Researchers are increasingly focused on understanding the molecular mechanisms by which TMUB2 influences cellular homeostasis and its potential as a therapeutic target. Recombinant TMUB2 protein studies allow for the detailed investigation of its structural and functional properties, facilitating the exploration of its interactions with other proteins and its role in relevant signaling pathways. Insights gained from such research could provide valuable information for the development of novel therapeutic strategies aimed at modulating TMUB2 activity in disease contexts. Moreover, as TMUB2 is expressed in various tissues, its study could have implications beyond oncology, extending to neurodegenerative diseases and metabolic disorders. Overall, understanding TMUB2's function and regulation may unveil new avenues for targeted therapies and contribute to a broader comprehension of cellular stress responses and protein homeostasis in health and disease.
