Cat: IPD-X33736

Recombinant Mouse Cystathionine gamma-lyase/CTH Protein,His

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Analytical Data

  • 基因名

    Cystathionine gamma-lyase/CTH

  • Application

    SPRMSTBLIITCELISA细胞实验药物筛选

  • 别名

    CSE; Cystathionase; Cysteine-protein sulfhydrase; Gamma-cystathionase

  • 种属

    Mouse

  • 表达系统

    E. coli

  • 标签

    N-His

  • 纯度

    Greater than 95% as determined by SDS-PAGE.

  • 蛋白编号

    Q8VCN5

  • 表达区间

    Phe14~Val224

  • 分子量

    27kDa

  • 内毒素

    < 1.0 EU per μg protein as determined by the LAL method.

  • 性状

    Freeze-dried powder

  • 缓冲液

    PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.

  • 复溶方法

    Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.

  • 个性化定制

    点位突变 标签定制 buffer定制 全长蛋白定制

  • 稳定性测试

    The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.

  • 保存条件 & 期限

    Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

  • 运输条件

    In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.

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Protein Description

Cystathionine gamma-lyase (CTH) is an important enzyme involved in the transsulfuration pathway, playing a crucial role in cysteine and hydrogen sulfide (H2S) production from cystathionine. This pathway is essential for maintaining cellular redox balance and protecting against oxidative stress. Dysregulation of CTH expression and activity has been implicated in various pathological conditions, including cardiovascular diseases, neurodegenerative disorders, and cancers. Recent research highlights the therapeutic potential of modulating H2S production, given its signaling properties and cytoprotective effects. Consequently, the recombinant expression of CTH has emerged as a valuable strategy to study its biochemical properties, characterize its catalytic mechanisms, and explore its therapeutic applications. In particular, the generation of recombinant CTH allows for detailed kinetic studies, structure-function analyses, and the evaluation of its role in cellular and physiological processes. Moreover, understanding the structure of CTH can facilitate the design of small molecule inhibitors or activators that may have significant implications in treating diseases associated with H2S dysregulation. Overall, the investigation of CTH recombinant protein is integral to advancing our understanding of sulfur metabolism and its implications in health and disease.

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Proteintech Group, Inc
5500 Pearl Street, Suite 400
Rosemont, IL 60018, USA
1-888-478-4522
proteintech@ptglab.com
IPODIX North America (HQ)
Proteintech Group, Inc
5500 Pearl Street, Suite 400
Rosemont, IL 60018, USA
1-888-478-4522
proteintech@ptglab.com
IPODIX North America (HQ)
Proteintech Group, Inc
5500 Pearl Street, Suite 400
Rosemont, IL 60018, USA
1-888-478-4522
proteintech@ptglab.com
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