Analytical Data
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Gene name
CA5A
- Application
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Alternative Names
CA-VA; CAVA; CAV; CA5; Carbonate dehydratase 5A, mitochondrial
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Species
Rat
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Source
E. coli
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Tag
N-His
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Purity
Greater than 95% as determined by SDS-PAGE.
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Uniprot
P43165
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Expression Region
Tyr12~Leu219
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Molecular Weight
26kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CA5A, or Carbonic Anhydrase 5A, is an enzyme belonging to the carbonic anhydrase family, which plays a crucial role in maintaining acid-base balance and facilitating carbon dioxide transport in the body. Research into CA5A has gained significant attention due to its potential implications in various physiological and pathological processes, including metabolism, respiration, and neurodegenerative diseases. With its unique catalytic properties, CA5A is involved in the hydration of carbon dioxide to bicarbonate and protons, a reaction vital for cellular functions and signaling pathways. Studies have shown that alterations in CA5A activity can be linked to disorders such as myopathies, respiratory insufficiencies, and certain types of cancers. Furthermore, its presence in specific tissues and its differential expression highlight its importance in certain biological contexts, prompting investigations into its roles in both health and disease. Understanding the structure-function relationships of CA5A and its regulatory mechanisms could pave the way for innovative therapeutic strategies, making it a promising target for drug development. Additionally, recombinant expression systems are being employed to produce CA5A for biochemical characterization and functional assays, allowing researchers to explore its potential applications in biotechnology and medicine. Overall, the study of CA5A represents a multidisciplinary approach, merging biochemistry, molecular biology, and clinical research, and holds promise for advancing our understanding of its biological significance and therapeutic potential.
