Analytical Data
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基因名
Can f 1
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简介
Can f 1 Protein is a major dog allergen. It is a protein produced in the canine VonEbner's glands and the possible role of the protein is in taste reception. Can f 1 is mainly derived from dog dander, pelt hair and saliva. Exposure and sensitization to dog allergen is a significant cause of asthma. Can f 1 Protein, Canine (HEK293, His) is the recombinant canine-derived Can f 1 protein, expressed by HEK293 , with C-His labeled tag.
- Application
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别名
Major allergen Can f 1; Allergen Dog 1; Can f 1
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种属
Canine
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表达系统
HEK293
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标签
C-6*His
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纯度
Greater than 95% as determined by SDS-PAGE.
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蛋白编号
O18873
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表达区间
Q19-Q174
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蛋白长度
Full Length of Mature Protein
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分子量
19-24 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Can f 1 is a significant allergen derived from the saliva of dogs, and it plays a crucial role in canine allergology. As one of the main allergens responsible for dog allergies in humans, studies focusing on Can f 1 recombinant protein have gained attention due to the increasing prevalence of pet-related allergies. Understanding the molecular structure and immunological properties of Can f 1 is essential for developing effective diagnostic tools and treatments, such as allergen-specific immunotherapy. The production of recombinant Can f 1 allows for the generation of standardized allergen preparations, facilitating the study of its allergenic potential and cross-reactivity with other allergens. Furthermore, research into the epitopes of Can f 1 can lead to the design of hypoallergenic dog breeds and the development of innovative therapeutic strategies to alleviate allergic symptoms in sensitized individuals. As pet ownership rises globally, the need for comprehensive studies on Can f 1 and its implications for human health becomes increasingly vital, underscoring the importance of recombinant protein research in the field of allergy and immunology.
