Analytical Data
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Gene name
AP-2 gamma/TFAP2C
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简介
The AP-2 gamma/TFAP2C protein is a sequence-specific DNA-binding factor that complexly regulates gene transcription by binding to enhancer elements. It recognizes the consensus sequence 5'-GCCNNNGGC-3' and activates genes critical for multiple developmental functions. AP-2 gamma/TFAP2C Protein, Human (His) is the recombinant human-derived AP-2 gamma/TFAP2C protein, expressed by E. coli , with N-His labeled tag.
- Application
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Alternative Names
Transcription factor AP-2 gamma; Transcription factor ERF-1
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Species
Human
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Source
E. coli
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Tag
N-10*His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q92754-1
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Expression Region
L128-V223
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Protein Length
Partial
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Molecular Weight
10-14 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
AP-2 gamma, also known as TFAP2C, is a member of the transcription factor AP-2 family, which plays a crucial role in various biological processes, including embryonic development, cellular differentiation, and tumorigenesis. The exploration of AP-2 gamma is particularly significant due to its involvement in regulating gene expression during important developmental stages and its potential implications in cancer biology. Research has demonstrated that AP-2 gamma can influence the transcription of genes associated with cell growth, apoptosis, and adhesion, indicating its vital role in maintaining cellular homeostasis. Dysregulation of AP-2 gamma has been linked to various malignancies, making it a candidate for therapeutic targeting. The study of recombinant AP-2 gamma/TFAP2C proteins in the lab facilitates a deeper understanding of its structure-function relationship and interaction with other molecular players. This knowledge can aid in elucidating its mechanism of action and impact on cellular pathways, contributing to the development of novel treatment strategies for diseases characterized by aberrant AP-2 gamma activity. As such, the research on AP-2 gamma not only provides insights into fundamental biological mechanisms but also holds promise for translational applications in cancer therapy and regenerative medicine.
