Analytical Data
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Gene name
TMEFF1/Tomoregulin-1
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简介
TMEFF1/Tomoregulin-1 protein may inhibit NODAL and BMP signaling in neural patterning, suggesting a regulatory role in neural development. It has been proposed as a tumor suppressor in brain cancer, emphasizing its importance in mitigating abnormal cell growth. TMEFF1/Tomoregulin-1 Protein, Human (HEK293, Fc) is the recombinant human-derived TMEFF1/Tomoregulin-1 protein, expressed by HEK293 , with C-hFc labeled tag.
- Application
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Alternative Names
TR-1; H7365; Transmembrane protein with EGF-like and one follistatin-like domain; C9orf2
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Species
Human
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Source
HEK293
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Tag
C-hFc
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q8IYR6
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Expression Region
S40-V330
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AA Sequence
SNQPPGGGGGSGGDCPGGKGKSINCSELNVRESDVRVCDESSCKYGGVCKEDGDGLKCACQFQCHTNYIPVCGSNGDTYQNECFLRRAACKHQKEITVIARGPCYSDNGSGSGEGEEEGSGAEVHRKHSKCGPCKYKAECDEDAENVGCVCNIDCSGYSFNPVCASDGSSYNNPCFVREASCIKQEQIDIRHLGHCTDTDDTSLLGKKDDGLQYRPDVKDASDQREDVYIGNHMPCPENLNGYCIHGKCEFIYSTQKASCRCESGYTGQHCEKTDFSILYVVPSRQKLTHV
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Protein Length
Extracellular Domain
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Molecular Weight
65 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
TMEFF1, also known as Tomoregulin-1, is a protein encoded by the TMEFF1 gene, which is located on chromosome 3 in humans. Initially discovered in the context of prostate cancer, TMEFF1 is recognized for its role in cell signaling and proliferation. It is a type I membrane protein that exhibits potential tumor-suppressive properties, influencing processes such as cellular growth, differentiation, and apoptosis. The protein interacts with various signaling pathways, including the epidermal growth factor (EGF) receptor cascade, suggesting its involvement in tumor biology. Research has indicated that TMEFF1 expression is often downregulated in several cancer types, which underscores its potential as a biomarker and therapeutic target. Additionally, studies have shown that TMEFF1 may exhibit neuroprotective effects, indicating its broader relevance in tissue homeostasis and regenerative processes. Given its multifunctional roles, the recombinant expression of TMEFF1 is being explored for therapeutic applications, including cancer treatment and neurological disorders. The development of TMEFF1 as a recombinant protein is crucial for further understanding its biological functions and mechanisms, ultimately paving the way for novel clinical interventions. Overall, the ongoing research into TMEFF1/Tomoregulin-1 represents a significant stride in deciphering the intricate interactions of cellular signaling pathways and their implications in human health and disease.
