Analytical Data
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基因名
S100A14
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简介
S100A14 Protein modulates P53/TP53 levels, influencing cell survival and apoptosis. It can either promote cell proliferation or apoptosis and regulates cell migration by modulating MMP2 levels, a P53/TP53-controlled matrix protease. S100A14 does not bind calcium. S100A14 Protein, Human (His) is the recombinant human-derived S100A14 protein, expressed by E. coli , with N-His labeled tag.
- Application
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别名
Protein S100-A14; S100 calcium-binding protein A14; S114; S100A14; S100A15
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种属
Human
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表达系统
E. coli
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标签
N-His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9HCY8.1
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表达区间
G2-H104
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蛋白长度
Partial
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分子量
13 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
S100A14 is a member of the S100 protein family, characterized by its capacity to bind calcium and other metal ions, which induces conformational changes allowing interaction with a variety of target proteins. Research into S100A14 has gained momentum due to its involvement in various cellular processes, such as cell proliferation, differentiation, and apoptosis, as well as its implications in several pathological conditions, including cancer and inflammatory diseases. Increased expression levels of S100A14 have been associated with tumor progression and poor prognosis in various malignancies, indicating its potential role as a biomarker for cancer diagnosis and therapy. Moreover, S100A14's diverse functions and regulatory mechanisms underscore its significance in cell signaling pathways. The study of recombinant S100A14 protein provides valuable insight into its structure-function relationships, enabling a better understanding of its biological activities and interactions at the molecular level. This research is crucial for identifying therapeutic targets and developing novel treatment strategies, particularly in oncology, where S100A14 may serve as a potential therapeutic agent or target for drug development. Through advanced techniques in protein expression and purification, scientists aim to elucidate the precise roles of S100A14 in health and disease, paving the way for its application in clinical settings.
