Analytical Data
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Gene name
S100A13
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简介
S100A13 Protein, acting as a homodimer, facilitates the export of signal peptide-lacking proteins through an alternative pathway, binding two calcium ions and one copper ion per subunit.It is crucial for the copper-dependent stress-induced export of IL1A and FGF1, with the calcium-free form binding to phosphatidylserine-containing lipid vesicles.S100A13 is part of a copper-dependent multiprotein complex, interacting with FGF1, SYT1, and IL1A.S100A13 Protein, Mouse (His) is the recombinant mouse-derived S100A13 protein, expressed by E.coli , with N-His labeled tag.
- Application
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Alternative Names
Protein S100-A13; S100A13; S100 calcium-binding protein A13
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Species
Mouse
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Source
E. coli
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Tag
N-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P97352
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Expression Region
M1-K98
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Protein Length
Full Length
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Molecular Weight
15 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
S100A13 is a member of the S100 family of proteins, which are characterized by their two calcium-binding sites and play crucial roles in various cellular processes, including cell proliferation, differentiation, and apoptosis. Research on S100A13 has gained interest due to its involvement in cancer progression and inflammation, as well as its potential as a biomarker for certain diseases. It has been observed that S100A13 is upregulated in various tumor types and is associated with enhanced cell motility and invasion, suggesting its role in tumor metastasis. Furthermore, S100A13 has been implicated in the regulation of exosome secretion and the modulation of apoptotic pathways, which highlights its significance in intercellular communication and the tumor microenvironment. The production of recombinant S100A13 protein allows researchers to elucidate its functional mechanisms and interactions at the molecular level, paving the way for therapeutic interventions targeting S100A13-related pathways. Understanding the structure-function relationships of S100A13 can provide insights into its biological roles and potential implications in disease contexts, making it a valuable protein in cancer research and beyond.
