Analytical Data
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Gene name
PGLYRP1/PGRP-S
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简介
PGLYRP1/PGRP-S Protein plays a vital role in the innate immune response.It recognizes bacterial peptidoglycan and activates antimicrobial defense mechanisms.PGLYRP1/PGRP-S Protein interacts with other immune molecules, enhancing immune responses against bacterial infections.Understanding its functions can aid in developing strategies to combat bacterial pathogens.PGLYRP1/PGRP-S Protein, Mouse (HEK293, His) is the recombinant mouse-derived PGLYRP1/PGRP-S protein, expressed by HEK293 , with C-His labeled tag.
- Application
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Alternative Names
Peptidoglycan recognition protein 1; Cytokine tag7; PGRP-S; Tag7; PGRP
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Species
Mouse
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Source
HEK293
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Tag
C-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
O88593
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Expression Region
F19-E182
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Protein Length
Full Length of Mature Protein
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Molecular Weight
18 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
PGLYRP1, also known as PGRP-S (peptidoglycan recognition protein 1), is part of a family of proteins that play crucial roles in the innate immune system by recognizing and binding to peptidoglycans from bacterial cell walls. This interaction is essential for the host's defense against bacterial infections, facilitating the activation of immune responses. PGLYRP1 is particularly important in environmental contexts where exposure to pathogens is frequent, as it helps in the identification and neutralization of harmful microbes. Research has shown that variations in PGLYRP1 expression levels can influence susceptibility to various infectious diseases and may even affect inflammatory responses. Understanding the structure and function of PGLYRP1, particularly through the study of recombinant forms of the protein, can provide insights into its mechanisms of action and potential therapeutic applications. As researchers develop recombinant PGLYRP1/PGRP-S proteins, studies aim to elucidate their binding affinities and specificities, which can lead to novel ways to enhance immune responses or develop antimicrobial agents. This research is significant not only for basic immunology but also for clinical applications, including vaccine development and the treatment of infections, highlighting the importance of PGLYRP1 in linking innate immunity and adaptive responses in the host defense system.
